Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation-Reference-Cited by-同舟云学术

Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation

Published:2015-06-16 Issue:381 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Xue Qiong¹,Lu Yao¹,Eisele Markus R.¹²,Sulistijo Endah S.¹,Khan Nafeesa¹,Fan Rong¹,Miller-Jensen Kathryn¹³

Affiliation:

1. Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

2. Institute for System Dynamics, University of Stuttgart, 70569 Stuttgart, Germany.

3. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.

Abstract

Comparing isolated cells with cell populations uncovers the contributions of autocrine and paracrine signaling to the secretion of cytokines by macrophages.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference61 articles.

1. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

2. Population robustness arising from cellular heterogeneity

3. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

4. Secreting and Sensing the Same Molecule Allows Cells to Achieve Versatile Social Behaviors

5. The Response of Human Epithelial Cells to TNF Involves an Inducible Autocrine Cascade

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