Frizzled does not get bent out of shape by Wnt-Reference-Cited by-同舟云学术

Frizzled does not get bent out of shape by Wnt

Published:2022-08-23 Issue:748 Volume:15 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Angers Stephane¹²³^ORCID

Affiliation:

1. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

2. Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

3. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.

Abstract

Ligands of the Wnt family activate the Frizzled-LRP5/6 receptor complex to initiate intracellular signaling. In this issue of Science Signaling , Mahoney et al. reveal a Wnt-stimulated positive feedback loop that involves local production of the lipid phosphatidylinositol(4,5)bisphosphate [PI(4,5)P 2 ], which promotes Dishevelled recruitment and additional PI(4,5)P 2 production, to facilitate LRP5/6 phosphorylation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference10 articles.

1. The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators

2. WNT-3A–induced β-catenin signaling does not require signaling through heterotrimeric G proteins

3. PI(4,5)P ₂ -stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt–β-catenin signaling

4. Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

5. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization

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