Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome-Reference-Cited by-同舟云学术

Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome

Author:

Inoue Makoto¹,Williams Kristi L.²,Oliver Timothy³,Vandenabeele Peter⁴⁵,Rajan Jayant V.⁶⁷,Miao Edward A.⁸,Shinohara Mari L.¹⁹

Affiliation:

1. Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

2. Departments of Medicine and Cardiology, Duke University Medical Center, Durham, NC 27710, USA.

3. Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

4. Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie (VIB), 9052 Ghent (Zwijnaarde), Belgium.

5. Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent (Zwijnaarde), Belgium.

6. Institute for Systems Biology, Seattle, WA 98103, USA.

7. Department of Medicine, University of Washington, Seattle, WA 98195, USA.

8. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

9. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Characterization of an animal model may explain why not all patients with multiple sclerosis respond to interferon-β.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference34 articles.

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