Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons-Reference-Cited by-同舟云学术

Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons

Published:2024-06-25 Issue:842 Volume:17 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Papassotiropoulos Andreas¹²³^ORCID,de Quervain Dominique J.-F.²³⁴^ORCID

Affiliation:

1. Division of Molecular Neuroscience, Department of Biomedicine, University of Basel, CH-4055 Basel, Switzerland.

2. Research Cluster Molecular and Cognitive Neurosciences, University of Basel, CH-4055 Basel, Switzerland.

3. Psychiatric University Clinics, University of Basel, CH-4055 Basel, Switzerland.

4. Division of Cognitive Neuroscience, Department of Biomedicine, University of Basel, CH-4055 Basel, Switzerland.

Abstract

WWC1 is a scaffolding protein in the evolutionarily conserved Hippo signaling network and is genetically linked to human memory and synaptic plasticity. In the archives of Science Signaling , Stepan et al. demonstrate the translational potential of modulating WWC1 through pharmacological inhibition of Hippo-pathway kinases to enhance cognition.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/scisignal.adp5354

Reference9 articles.

1. Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

2. Common Kibra Alleles Are Associated with Human Memory Performance

3. KIBRA is a novel substrate for protein kinase Cζ

4. Regulation of AMPA Receptor Function by the Human Memory-Associated Gene KIBRA

5. Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice