Global Phosphoproteomics Reveals Crosstalk Between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling

Author:

Rubbi Liudmilla1234,Titz Björn1234,Brown Lauren1234,Galvan Erica1234,Komisopoulou Evangelia1234,Chen Sharon S.1234,Low Tracey1234,Tahmasian Martik1234,Skaggs Brian5,Müschen Markus6,Pellegrini Matteo78,Graeber Thomas G.12348

Affiliation:

1. Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

2. Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

3. Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

4. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

5. Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

6. Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA.

7. Institute for Genomics and Proteomics; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.

8. California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA.

Abstract

Negative feedback fails to limit Src family kinase activity in the presence of Bcr-Abl, an oncoprotein that drives leukemia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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