The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway-Reference-Cited by-同舟云学术

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

Published:2015-05-19 Issue:377 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sjölin-Goodfellow Hanna¹²,Frushicheva Maria P.³,Ji Qinqin⁴,Cheng Debra A.¹²,Kadlecek Theresa A.¹²,Cantor Aaron J.⁵⁶,Kuriyan John⁵⁶⁷⁸⁹,Chakraborty Arup K.³¹⁰¹¹¹²¹³,Salomon Arthur R.⁴¹⁴,Weiss Arthur¹²

Affiliation:

1. Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

3. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Department of Chemistry, Brown University, Providence, RI 02912, USA.

5. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

6. California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA.

7. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

8. Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

9. Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

10. Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

11. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

12. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

13. Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

14. Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.

Abstract

The kinase ZAP-70 has both positive and negative functions in T cell signaling.

Funder

NIH

Wenner-Gren Foundations

Stiftelsen Blanceflor Boncompagni Ludovisi

Sweden-America Foundation

Cancer Research Institute Irvington Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference94 articles.

1. T Cell Activation

2. T cell receptor signalling networks: branched, diversified and bounded

3. Adaptors as central mediators of signal transduction in immune cells

4. Novel Tools to Dissect the Dynamic Regulation of TCR Signaling by the Kinase Csk and the Phosphatase CD45

5. Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

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