Protein Kinase CK2 Triggers Cytosolic Zinc Signaling Pathways by Phosphorylation of Zinc Channel ZIP7

Author:

Taylor Kathryn M.1,Hiscox Stephen1,Nicholson Robert I.1,Hogstrand Christer2,Kille Peter3

Affiliation:

1. Breast Cancer Molecular Pharmacology Group, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VIIth Avenue, Cardiff CF10 3NB, UK.

2. Metals Metabolism Group, Diabetes and Nutritional Sciences Division, King’s College London, 3.85 Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

3. Department of Biosciences, Cardiff University, Main Building, Museum Avenue, Cardiff CF10 3AT, UK.

Abstract

Phosphorylation of the zinc channel ZIP7 releases zinc from the endoplasmic reticulum and promotes signals associated with proliferation and migration.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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