Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders-Reference-Cited by-同舟云学术

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

Published:2015-05-12 Issue:376 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Daniele Stefano G.¹,Béraud Dawn¹²,Davenport Connor¹,Cheng Kui³⁴,Yin Hang³⁴,Maguire-Zeiss Kathleen A.¹²

Affiliation:

1. Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.

2. Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.

3. Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80309, USA.

4. Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Abstract

Patients with neurodegenerative disorders called synucleinopathies may benefit from drugs that inhibit inflammatory receptors on microglia in the brain.

Funder

Parkinson's Disease Foundation Summer Student Fellowship

NIH/National Institute of Neurological Disorders and Stroke

NIH

NIH/National Institute of Environmental Health Sciences

Parkinson's Movement Disorder Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference128 articles.

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2. Genetic Analysis of Families with Parkinson Disease that Carry the Ala53Thr Mutation in the Gene Encoding α-Synuclein

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4. Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

5. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

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