A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication-Reference-Cited by-同舟云学术

A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Published:2013-02-12 Issue:262 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hubbi Maimon E.¹²,Kshitiz ¹³⁴,Gilkes Daniele M.¹²,Rey Sergio¹²,Wong Carmen C.¹²,Luo Weibo¹⁵,Kim Deok-Ho⁴,Dang Chi V.⁶,Levchenko Andre¹³,Semenza Gregg L.¹²⁵⁶⁷

Affiliation:

1. Vascular Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

2. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

4. Department of Bioengineering, School of Medicine, University of Washington, Seattle, WA 98195, USA.

5. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

6. Departments of Medicine and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

7. Departments of Pediatrics and Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

In response to hypoxia, HIF-1α induces cell cycle arrest by inhibiting a helicase complex that unwinds DNA in preparation for replication.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.;Semenza G. L.;Mol. Cell. Biol.,1992

2. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

3. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

4. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

5. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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