Drug Synergy Screen and Network Modeling in Dedifferentiated Liposarcoma Identifies CDK4 and IGF1R as Synergistic Drug Targets-Reference-Cited by-同舟云学术

Drug Synergy Screen and Network Modeling in Dedifferentiated Liposarcoma Identifies CDK4 and IGF1R as Synergistic Drug Targets

Published:2013-09-24 Issue:294 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Miller Martin L.¹,Molinelli Evan J.¹²,Nair Jayasree S.³,Sheikh Tahir³,Samy Rita¹,Jing Xiaohong¹,He Qin¹,Korkut Anil¹,Crago Aimee M.⁴,Singer Samuel⁴,Schwartz Gary K.³⁵,Sander Chris¹

Affiliation:

1. Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

2. Tri-Institutional Training Program in Computational Biology and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

3. Laboratory of New Drug Development, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

4. Sarcoma Disease Management Program, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

5. Melanoma and Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Drug screening and computational modeling of oncogenic signaling pathways identifies synergistic drug pairs for liposarcoma.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference96 articles.

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5. Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas

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