Acute O 2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors-Reference-Cited by-同舟云学术

Acute O 2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

Published:2020-01-21 Issue:615 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Moreno-Domínguez Alejandro¹²^ORCID,Ortega-Sáenz Patricia¹²³^ORCID,Gao Lin¹²³^ORCID,Colinas Olalla¹²,García-Flores Paula¹²³,Bonilla-Henao Victoria¹²³,Aragonés Julián⁴⁵^ORCID,Hüttemann Maik⁶^ORCID,Grossman Lawrence I.⁶^ORCID,Weissmann Norbert⁷^ORCID,Sommer Natascha⁷,López-Barneo José¹²³^ORCID

Affiliation:

1. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville 41013, Spain.

2. Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Seville 41009, Spain.

3. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Seville 41013, Spain.

4. Research Unit, Hospital of Santa Cristina, Research Institute Princesa (IP), Autonomous University of Madrid, Madrid 28009, Spain.

5. CIBER de Enfermedades Cardiovasculares, Madrid 28009, Spain.

6. Center for Molecular Medicine and Genetics, Wayne State University, School of Medicine, Detroit, MI 48201, USA.

7. Excellence Cluster Cardiopulmonary System, University of Giessen and Marburg Lung Centre (UGMLC), German Centre for Lung Research (DZL), Justus-Liebig-University, Giessen 35392, Germany.

Abstract

HIF2α-mediated gene expression enables the carotid body to respond to acute hypoxia.

Funder

H2020 European Research Council

Spanish Ministries of Science and Innovation and Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference76 articles.

1. Acute Oxygen-Sensing Mechanisms

2. The Ventilatory Response to Hypoxia in Mammals: Mechanisms, Measurement, and Analysis