The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage-Reference-Cited by-同舟云学术

The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage

Published:2015-06-30 Issue:383 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Tu Chi-Chiang¹²,Zhong Yan¹,Nguyen Louis¹,Tsai Aaron¹,Sridevi Priya¹,Tarn Woan-Yuh²,Wang Jean Y. J.¹

Affiliation:

1. Moores Cancer Center and Division of Hematology-Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093–0644, USA.

2. Institute of Biomedical Sciences, Academia Sinica, Taipei 11529 Taiwan.

Abstract

DNA damage triggers the biogenesis of some miRNAs through the activity of the kinase ABL.

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference63 articles.

1. Mammalian microRNAs predominantly act to decrease target mRNA levels

2. Regulation of non-coding RNA networks in the nervous system—What's the REST of the story?

3. Most mammalian mRNAs are conserved targets of microRNAs

4. The Microprocessor complex mediates the genesis of microRNAs

5. Biogenesis of small RNAs in animals

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