Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein α Subunit Membrane Association-Reference-Cited by-同舟云学术

Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein α Subunit Membrane Association

Published:2011-11-22 Issue:200 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gabay Meital¹,Pinter Mary E.¹,Wright Forrest A.¹,Chan PuiYee¹,Murphy Andrew J.²,Valenzuela David M.²,Yancopoulos George D.²,Tall Gregory G.¹

Affiliation:

1. Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.

2. Regeneron Pharmaceuticals Inc., Tarrytown, NY 10510, USA.

Abstract

Control of the insertion of G protein α subunits into endomembranes by Ric-8 proteins regulates the abundance and function of heterotrimeric G proteins.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference66 articles.

1. Ric-8B Is a GTP-dependent G Protein αs Guanine Nucleotide Exchange Factor

2. Mammalian Ric-8A (Synembryn) Is a Heterotrimeric Gα Protein Guanine Nucleotide Exchange Factor

3. A genetic selection for Caenorhabditis elegans synaptic transmission mutants.;Miller K. G.;Proc. Natl. Acad. Sci. U.S.A.,1996

4. RIC-8 (synembryn): A novel conserved protein that is required for Gqα signaling in the C. elegans nervous system.;Miller K. G.;Neuron,2000

5. A role for RIC-8 (synembryn) and GOA-1 (Goα) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans.;Miller K. G.;Genetics,2000

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