A Synthetic Biology Approach Reveals a CXCR4-G 13 -Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells-Reference-Cited by-同舟云学术

A Synthetic Biology Approach Reveals a CXCR4-G 13 -Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells

Published:2011-09-20 Issue:191 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Yagi Hiroshi¹,Tan Wenfu¹,Dillenburg-Pilla Patricia¹,Armando Sylvain²,Amornphimoltham Panomwat³,Simaan May¹,Weigert Roberto³,Molinolo Alfredo A.¹,Bouvier Michel²,Gutkind J. Silvio¹

Affiliation:

1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.

2. Department of Biochemistry, Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3C 3J7, Canada.

3. Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.

Abstract

Interfering with a specific G protein–coupled receptor pathway may provide a therapeutic approach to blocking metastasis of some forms of breast cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference66 articles.

1. Histological and molecular types of breast cancer: is there a unifying taxonomy?

2. Triple-negative breast cancer—current status and future directions

3. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

4. Cancer Metastasis: Building a Framework

5. G-protein-coupled receptors and cancer

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