Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes-Reference-Cited by-同舟云学术

Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes

Published:2021-03-09 Issue:673 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Metzemaekers Mieke¹²^ORCID,Mortier Anneleen¹,Vacchini Alessandro²³^ORCID,Boff Daiane¹⁴,Yu Karen¹^ORCID,Janssens Rik¹⁴,Farina Floriana M.²^ORCID,Milanesi Samantha²³^ORCID,Berghmans Nele¹,Pörtner Noëmie¹,Van Damme Jo¹,Allegretti Marcello⁵^ORCID,Teixeira Mauro M.⁴^ORCID,Locati Massimo²³^ORCID,Borroni Elena M.²³^ORCID,Amaral Flavio A.⁴^ORCID,Proost Paul¹^ORCID

Affiliation:

1. Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49 box 1042, Leuven B-3000, Belgium.

2. Humanitas Clinical and Research Center, IRCCS, via Manzoni 56, 20089 Rozzano, Milan, Italy.

3. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Via Fratelli Cervi 93, I-20090 Segrate, Italy.

4. Imunofarmacologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, Minas Gerais 31270-901, Brasil.

5. Dompé Farmaceutici SpA, L’Aquila, Italy.

Abstract

Proteolytic processing of CXCL5 potentiates its chemoattractant activity toward neutrophils and monocytes in vitro and in vivo.

Funder

United Nations Educational, Scientific and Cultural Organization

Horizon 2020 Framework Programme

Hercules Foundation

Fonds Wetenschappelijk Onderzoek

Herculesstichting

Vlaamse regering

Koç Üniversitesi

KU Leuven