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Regulation of the EGF Transcriptional Response by Endocytic Sorting

Published:2012-03-13 Issue:215 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Brankatschk Ben¹,Wichert Sven P.²,Johnson Shem D.¹,Schaad Olivier¹³,Rossner Moritz J.²,Gruenberg Jean¹

Affiliation:

1. Department of Biochemistry, University of Geneva, 30 Quai E. Ansermet, 1211 Geneva 4, Switzerland.

2. Research Group Gene Expression, Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Goettingen, Germany.

3. Genomics Platform, CMU, University of Geneva, 1 Rue Michel-Servet, 1211 Geneva 4, Switzerland.

Abstract

The transcriptional response to EGFR activation is rapidly initiated after receptor stimulation before degradative sorting occurs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference84 articles.

1. Epidermal Growth Factor

2. Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

3. Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells.

4. Binding and Internalization of Epidermal Growth Factor in Human Term Placental Cells in Culture*

5. Multivesicular bodies: co-ordinated progression to maturity

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