Gα i1 and Gα i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway-Reference-Cited by-同舟云学术

Gα i1 and Gα i3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway

Published:2009-04-28 Issue:68 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Cao Cong¹²,Huang Xuesong¹,Han Yuyuan¹,Wan Yinsheng³,Birnbaumer Lutz⁴,Feng Geng-Sheng⁵,Marshall John⁶,Jiang Meisheng⁷,Chu Wen-Ming¹²

Affiliation:

1. Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

2. Pathobiology Graduate Program, Brown University, Providence, RI 02912, USA.

3. Department of Biology, Providence College, Providence, RI 02918, USA.

4. Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

5. Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

6. Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA.

7. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Abstract

Two members of the Gα i family of G proteins form complexes with EGFR and the adaptor protein Gab1 to mediate activation of Akt.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference51 articles.

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4. FOXO transcription factors in ageing and cancer

5. FOXO transcription factors: key regulators of cell fate

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