The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression-Reference-Cited by-同舟云学术

The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression

Published:2017-04-04 Issue:473 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Becchetti Andrea¹^ORCID,Crescioli Silvia²^ORCID,Zanieri Francesca²,Petroni Giulia²,Mercatelli Raffaella³,Coppola Stefano⁴,Gasparoli Luca²^ORCID,D’Amico Massimo⁵,Pillozzi Serena²^ORCID,Crociani Olivia²,Stefanini Matteo⁵,Fiore Antonella²,Carraresi Laura⁵,Morello Virginia⁶,Manoli Sagar²,Brizzi Maria Felice⁷^ORCID,Ricci Davide⁸^ORCID,Rinaldi Mauro⁸,Masi Alessio²^ORCID,Schmidt Thomas⁴,Quercioli Franco³^ORCID,Defilippi Paola⁴^ORCID,Arcangeli Annarosa²^ORCID

Affiliation:

1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.

2. Department of Experimental and Clinical Medicine, University of Firenze, Viale G.B. Morgagni 50, 50134 Firenze, Italy.

3. Consiglio Nazionale delle Ricerche–Istituto Nazionale di Ottica, Via N. Carrara 1, 50019 Sesto Fiorentino, Italy.

4. Physics of Life Processes, Huygens-Kamerlingh Onnes Laboratory, Leiden University, Niels Bohrweg 2, 2333 CA Leiden, Netherlands.

5. Di.V.A.L. Toscana SRL, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Italy.

6. Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Italy.

7. Department of Medical Sciences, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy.

8. Department of Surgical Sciences, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy.

Abstract

Whether hERG1 potassium channels promote proliferation or metastasis in breast cancer cells depends on channel conformation.

Funder

Associazione Italiana per la Ricerca sul Cancro

Association for International Cancer Research

IonTraC

Associazione Genitori Noi per Voi

FRRB-Nanofarmaci

University of Milano-Bicocca

University of Firenze

Italian Foundation for Cancer Research Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference65 articles.

1. New Insights into the Regulation of Ion Channels by Integrins

2. Role of Ion Channels and Transporters in Cell Migration

3. Complex functional interaction between integrin receptors and ion channels

4. Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk

5. Integrins

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