Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells-Reference-Cited by-同舟云学术

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

Published:2018-09-25 Issue:549 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Foulkes Daniel M.¹^ORCID,Byrne Dominic P.¹,Yeung Wayland²^ORCID,Shrestha Safal²^ORCID,Bailey Fiona P.¹,Ferries Samantha¹³,Eyers Claire E.¹³^ORCID,Keeshan Karen⁴^ORCID,Wells Carrow⁵^ORCID,Drewry David H.⁵^ORCID,Zuercher William J.⁵⁶^ORCID,Kannan Natarajan²,Eyers Patrick A.¹^ORCID

Affiliation:

1. Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.

2. Institute of Bioinformatics and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

3. Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.

4. Paul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Scotland, UK.

5. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Covalent EGFR family inhibitors bind to and induce the degradation of the pseudokinase TRIB2 to kill cancer cells.

Funder

North West Cancer Research Fund

BBSRC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference105 articles.

1. Dawn of the dead: protein pseudokinases signal new adventures in cell biology

2. Structural Basis for the Non-catalytic Functions of Protein Kinases

3. Pseudokinases: update on their functions and evaluation as new drug targets

4. Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

5. Tribbles pseudokinases: novel targets for chemical biology and drug discovery?

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