Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response-Reference-Cited by-同舟云学术

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

Published:2015-12 Issue:405 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sun Yonglian¹,Peng Ivan¹,Webster Joshua D.²,Suto Eric¹,Lesch Justin¹,Wu Xiumin¹,Senger Kate¹,Francis George³,Barrett Kathy³,Collier Jenna L.¹,Burch Jason D.⁴,Zhou Meijuan¹,Chen Yuan⁵,Chan Connie⁵,Eastham-Anderson Jeff²,Ngu Hai²,Li Olga⁶,Staton Tracy⁶,Havnar Charles²,Jaochico Allan⁵,Jackman Janet¹,Jeet Surinder¹,Riol-Blanco Lorena¹,Wu Lawren C.¹,Choy David F.⁷,Arron Joseph R.¹,McKenzie Brent S.¹,Ghilardi Nico¹,Ismaili Moulay Hicham Alaoui³,Pei Zhonghua⁴,DeVoss Jason¹,Austin Cary D.²,Lee Wyne P.¹,Zarrin Ali A.¹

Affiliation:

1. Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.

2. Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.

3. Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.

4. Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.

5. Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.

6. Department of Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA.

7. Department of Immunology, Tissue Growth, and Repair Diagnostics Discovery, Genentech Inc., South San Francisco, CA 94080, USA.

Abstract

The kinase ITK is required for antigen-stimulated T cell death.

Funder

Genentech

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference55 articles.

1. itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

2. TEC FAMILY KINASES IN T LYMPHOCYTE DEVELOPMENT AND FUNCTION

3. T-Cell Signaling Regulated by the Tec Family Kinase, Itk

4. Regulation of T-cell Responses and Disease by Tec Kinase Itk

5. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

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