Ca 2+ -dependent demethylation of phosphatase PP2Ac promotes glucose deprivation–induced cell death independently of inhibiting glycolysis-Reference-Cited by-同舟云学术

Ca 2+ -dependent demethylation of phosphatase PP2Ac promotes glucose deprivation–induced cell death independently of inhibiting glycolysis

Published:2018-01-09 Issue:512 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Lee Ha Yin¹^ORCID,Itahana Yoko¹^ORCID,Schuechner Stefan²^ORCID,Fukuda Masahiro³,Je H. Shawn³^ORCID,Ogris Egon²,Virshup David M.¹⁴⁵,Itahana Koji¹^ORCID

Affiliation:

1. Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore.

2. Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Dr. Bohr-Gasse 9, 1030 Vienna, Austria.

3. Programme in Neuroscience and Behavioural Disorders, Duke-NUS Medical School, 8 College Road, 169857, Singapore.

4. Department of Biochemistry, National University of Singapore, 8 Medical Drive, 117596, Singapore.

5. Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

Abstract

Glucose starvation triggers cell death through a calcium-dependent signaling pathway independently of cell energy metabolism.

Funder

Singapore Ministry of Health’s National Medical Research Council grant

Singapore Ministry of Education Academic Research Fund Tier 2 grant

Khoo Postdoctoral Fellowship Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference117 articles.

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