Proteomics profiling of arginine methylation defines PRMT5 substrate specificity-Reference-Cited by-同舟云学术

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

Published:2019-04-02 Issue:575 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Musiani Daniele¹^ORCID,Bok Jabez²^ORCID,Massignani Enrico¹^ORCID,Wu Liling²³,Tabaglio Tommaso²³^ORCID,Ippolito Marica Rosaria¹,Cuomo Alessandro¹,Ozbek Umut⁴⁵,Zorgati Habiba²³,Ghoshdastider Umesh²,Robinson Robert C.²³,Guccione Ernesto²³⁶⁷^ORCID,Bonaldi Tiziana¹^ORCID

Affiliation:

1. Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

2. Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore.

3. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.

4. Department of Population Health Science and Policy, Mount Sinai, New York, NY 10029, USA.

5. Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.

6. Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

7. Department of Pharmacological Sciences and Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

Proteomics identifies target sites and substrates of the arginine methyltransferase PRMT5.

Funder

National Research Foundation-Prime Minister’s office, Republic of Singapore

Ministry of Education - Singapore

Associazione Italiana per la Ricerca sul Cancro

Italian Ministry of Health

National Research Council Italia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry