Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors-Reference-Cited by-同舟云学术

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

Published:2018-12-04 Issue:559 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Namkung Yoon¹^ORCID,LeGouill Christian²^ORCID,Kumar Sahil¹,Cao Yubo³,Teixeira Larissa B.²⁴,Lukasheva Viktoriya²^ORCID,Giubilaro Jenna³,Simões Sarah C.⁴,Longpré Jean-Michel⁵^ORCID,Devost Dominic³^ORCID,Hébert Terence E.³,Piñeyro Graciela⁶,Leduc Richard⁵,Costa-Neto Claudio M.⁴^ORCID,Bouvier Michel²^ORCID,Laporte Stéphane A.¹³⁷^ORCID

Affiliation:

1. Department of Medicine, Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montréal, QC H4A 3J1, Canada.

2. Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, QC H3T 1J4, Canada.

3. Department of Pharmacology and Therapeutics, McGill University, Montréal, QC H3G 1Y6, Canada.

4. Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo 14049-900, Brazil.

5. Institut de Pharmacologie de Sherbrooke and Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

6. Centre de Recherche de l’Hôpital Sainte-Justine, Montréal, QC H3T 1C5, Canada.

7. Department of Anatomy and Cell Biology, McGill University, Montréal, QC H3A 0C7, Canada.

Abstract

Bioluminescence-based biosensors enable comprehensive profiling of G protein–coupled receptor signaling bias.

Funder

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference81 articles.

1. Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors

2. Mammalian G Proteins and Their Cell Type Specific Functions

3. Molecular Basis of Receptor/G-Protein-Coupling Selectivity

4. Drug Efficacy at G Protein–Coupled Receptors

5. β-arrestin-mediated receptor trafficking and signal transduction

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