Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling-Reference-Cited by-同舟云学术

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling

Published:2017-08-29 Issue:494 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Uehara Shunsuke¹^ORCID,Udagawa Nobuyuki¹,Mukai Hideyuki²^ORCID,Ishihara Akihiro³,Maeda Kazuhiro⁴,Yamashita Teruhito⁵,Murakami Kohei¹^ORCID,Nishita Michiru⁶,Nakamura Takashi⁷,Kato Shigeaki⁸⁹,Minami Yasuhiro⁶,Takahashi Naoyuki⁵,Kobayashi Yasuhiro⁵^ORCID

Affiliation:

1. Department of Biochemistry, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.

2. Biosignal Research Center, Kobe University, Kobe, Hyogo 657-8501, Japan.

3. Department of Periodontology, Tokyo Medical and Dental University, Tokyo 113-0034, Japan.

4. Department of Orthopedic Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.

5. Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano 399-0781, Japan.

6. Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Hyogo 650-0017, Japan.

7. Department of Biochemistry, Tokyo Dental College, Tokyo 101-0061, Japan.

8. Center for Regional Cooperation, Iwaki Meisei University, Iwaki, Fukushima 970-8551, Japan.

9. Research Institute of Innovative Medicine, Tokiwa Foundation, Iwaki, Fukushima 972-8322, Japan.

Abstract

A signaling pathway that promotes the cytoskeleton remodeling in osteoclasts necessary for bone resorption is elucidated.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. Actin, a Central Player in Cell Shape and Movement

2. Origins of Cell Polarity

3. Rho GTPases and the Actin Cytoskeleton

4. The cell biology of osteoclast function

5. The osteoclast and its unique cytoskeleton

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