A signaling network stimulated by β 2 integrin promotes the polarization of lytic granules in cytotoxic cells-Reference-Cited by-同舟云学术

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A signaling network stimulated by β 2 integrin promotes the polarization of lytic granules in cytotoxic cells

Published:2014-10-07 Issue:346 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zhang Minggang¹,March Michael E.¹,Lane William S.²,Long Eric O.¹

Affiliation:

1. Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

2. Mass Spectrometry and Proteomics Resource Laboratory, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

Distinct pathways activated by an integrin in natural killer cells enable the polarization of lytic granules required for target cell killing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference58 articles.

1. Integrin inside-out signaling and the immunological synapse

2. LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

3. LFA-1 Contributes an Early Signal for NK Cell Cytotoxicity

4. Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells

5. β2 Integrin Induces TCRζ–Syk–Phospholipase C-γ Phosphorylation and Paxillin-Dependent Granule Polarization in Human NK Cells

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