The Ca 2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain

Author:

Son Ga-Yeon1ORCID,Tu Nguyen Huu2ORCID,Santi Maria Daniela2ORCID,Loya Lopez Santiago13ORCID,Souza Bomfim Guilherme H.1ORCID,Vinu Manikandan4,Zhou Fang5ORCID,Chaloemtoem Ariya4ORCID,Alhariri Rama4ORCID,Idaghdour Youssef4ORCID,Khanna Rajesh13ORCID,Ye Yi23,Lacruz Rodrigo S.1ORCID

Affiliation:

1. Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA.

2. NYU Dentistry Translational Research Center, Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY 10010, USA.

3. New York University Pain Research Center, New York University, New York, NY 10010.

4. Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates.

5. Department of Pathology, New York University Langone Health, New York, NY 10010, USA.

Abstract

Oral cancer causes pain associated with cancer progression. We report here that the function of the Ca 2+ channel ORAI1 is an important regulator of oral cancer pain. ORAI1 was highly expressed in tumor samples from patients with oral cancer, and ORAI1 activation caused sustained Ca 2+ influx in human oral cancer cells. RNA-seq analysis showed that ORAI1 regulated many genes encoding oral cancer markers such as metalloproteases (MMPs) and pain modulators. Compared with control cells, oral cancer cells lacking ORAI1 formed smaller tumors that elicited decreased allodynia when inoculated into mouse paws. Exposure of trigeminal ganglia neurons to MMP1 evoked an increase in action potentials. These data demonstrate an important role of ORAI1 in oral cancer progression and pain, potentially by controlling MMP1 abundance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. “Gatekeepers of heaven” breaking bad;Cell Calcium;2024-03

2. Advanced Dental Research in the World;Indian Journal of Dental Research;2023

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