DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway-Reference-Cited by-同舟云学术

DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway

Published:2022-01-04 Issue:715 Volume:15 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Liu Liu¹²^ORCID,Dai Xiaoming³^ORCID,Yin Shasha¹²,Liu Pengda⁴^ORCID,Hill Elizabeth G.²⁵^ORCID,Wei Wenyi³^ORCID,Gan Wenjian¹²^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

2. Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

3. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

4. Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

5. Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

How the DNA damage response promotes cell survival through the kinase DNA-PK is revealed.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference72 articles.

1. PI3K-PKB/Akt Pathway

2. AKT/PKB Signaling: Navigating the Network

3. Hallmarks of Cancer: The Next Generation

4. Delayed mammary gland involution in MMTV-AKT1 transgenic mice

5. Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression

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