Matrix Rigidity Controls Endothelial Differentiation and Morphogenesis of Cardiac Precursors-Reference-Cited by-同舟云学术

Matrix Rigidity Controls Endothelial Differentiation and Morphogenesis of Cardiac Precursors

Published:2012-06-05 Issue:227 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kshitiz ¹²,Hubbi Maimon E.²,Ahn Eun Hyun³,Downey John¹,Afzal Junaid⁴,Kim Deok-Ho¹⁵,Rey Sergio²,Chang Connie¹,Kundu Arnab¹²,Semenza Gregg L.²⁴⁶⁷,Abraham Roselle M.⁴,Levchenko Andre¹²⁸

Affiliation:

1. Department of Biomedical Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

2. Vascular Biology, Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

3. Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98195, USA.

4. Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

5. Department of Bioengineering, School of Medicine, University of Washington, Seattle, WA 98195, USA.

6. Departments of Pediatrics, Oncology, Radiation Oncology, and Biological Chemistry, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

7. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

8. Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

Culturing cardiac precursors on a surface with the rigidity of heart tissue increases the yield of endothelial cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference54 articles.

1. Substrate Rigidity Regulates the Formation and Maintenance of Tissues

2. Local force and geometry sensing regulate cell functions

3. Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties