The G protein α subunit variant XLα s promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo-Reference-Cited by-同舟云学术

The G protein α subunit variant XLα s promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo

Author:

He Qing¹,Zhu Yan¹,Corbin Braden A.¹,Plagge Antonius²,Bastepe Murat¹

Affiliation:

1. Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

2. Department of Cellular and Molecular Physiology, Institute of Translational Medicine University of Liverpool, Liverpool L69 3BX, UK.

Abstract

The extra-large Gα subunit that mediates the effects of parathyroid hormone on the kidney stimulates two distinct downstream pathways.

Funder

National Center for Research Resources

National Center for Advancing Translational Sciences

NIH

NIH/National Institute of Diabetes and Digestive and Kidney Diseases

NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference59 articles.

3. Endocrine manifestations of stimulatory G protein α-subunit mutations and the role of genomic imprinting;Weinstein L. S.;Endocr. Rev.,2001

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