The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation-Reference-Cited by-同舟云学术

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation

Published:2018-10-23 Issue:553 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Shen Kexin¹²^ORCID,Moroco Jamie A.³^ORCID,Patel Ravi K.¹,Shi Haibin¹^ORCID,Engen John R.³^ORCID,Dorman Heather R.¹^ORCID,Smithgall Thomas E.¹^ORCID

Affiliation:

1. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

2. Tsinghua University School of Medicine, Beijing 100084, China.

3. Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.

Abstract

Sequence differences in the Src family kinase Fgr decrease its autoinhibitory regulation and increase its sensitivity to a myeloproliferative cytokine.

Funder

National Cancer Institute

National Institute of General Medical Sciences

China Scholarship Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. Src family kinases, key regulators of signal transduction

2. A renaissance for SRC

3. The interplay between Src and integrins in normal and tumor biology

4. Targeting Src family kinases in anti-cancer therapies: turning promise into triumph

5. Src family kinases and their role in hematological malignancies

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