Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract

Author:

Mills Jason C.1,Sansom Owen J.2

Affiliation:

1. Division of Gastroenterology, Departments of Medicine, Pathology & Immunology, and Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

Abstract

Mechanisms of cellular reprogramming fuel cancer development and progression in the gastrointestinal tract.

Funder

Cancer Research UK

European Research Council

NIH National Institute of Diabetes and Digestive and Kidney Diseases

Barnes Hospital Foundation Cancer Frontier Fund

American Cancer Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference162 articles.

1. C. H. Waddington The Strategy of the Genes. A Discussion of Some Aspects of Theoretical Biology (George Allen & Unwin London 1957).

2. The Fine Structure of Blastema Cells and Differentiating Cartilage Cells in Regenerating Limbs of Amblystoma Larvae

3. Expression of pluripotency factors in echinoderm regeneration

4. Observations on evisceration and visceral regeneration in the sea-cucumber, Actinopyga agassizi Selenka;Mosher C.;Zoologica,1956

5. The Stem State: Plasticity Is Essential, Whereas Self‐Renewal and Hierarchy Are Optional

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