Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists-Reference-Cited by-同舟云学术

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Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists

Published:2017-08-22 Issue:493 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Boltaev Umed¹²^ORCID,Meyer Yves¹^ORCID,Tolibzoda Farangis¹²^ORCID,Jacques Teresa¹^ORCID,Gassaway Madalee¹²^ORCID,Xu Qihong³^ORCID,Wagner Florence³,Zhang Yan-Ling³,Palmer Michelle³,Holson Edward³,Sames Dalibor¹²^ORCID

Affiliation:

1. Department of Chemistry, Columbia University, New York, NY 10027, USA.

2. NeuroTechnology Center at Columbia University, New York, NY 10027, USA.

3. Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Quantitative assays suggest that several reported agonists of the receptor TrkB do not indeed activate TrkB signaling.

Funder

G Harold and Leila Y. Mathers Foundation

Stanley Medical Research Institute, Broad Institute of MIT, and Harvard University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference66 articles.

1. TrkB signalling pathways in LTP and learning

2. Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease;Yoshii A.;Dev. Neurobiol.,2010

3. BDNF and memory processing

4. Synaptic regulation of affective behaviors; role of BDNF

5. BDNF and Synaptic Plasticity, Cognitive Function, and Dysfunction

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