MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity-Reference-Cited by-同舟云学术

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity

Published:2017-10-31 Issue:503 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sandí María-José¹^ORCID,Marshall Christopher B.¹,Balan Marc¹²^ORCID,Coyaud Étienne¹,Zhou Ming³,Monson Daniel M.³,Ishiyama Noboru¹,Chandrakumar Arun A.¹²,La Rose José¹^ORCID,Couzens Amber L.⁴^ORCID,Gingras Anne-Claude⁴⁵^ORCID,Raught Brian¹²,Xu Wei⁶⁷,Ikura Mitsuhiko¹²,Morrison Deborah K.³^ORCID,Rottapel Robert¹²⁸⁹¹⁰^ORCID

Affiliation:

1. Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada.

2. Department of Medical Biophysics, University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada.

3. Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA.

4. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

5. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

6. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

7. Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

8. Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

9. Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

10. Division of Rheumatology, St. Michael’s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.

Abstract

A phosphorylation switch releases sequestered ARHGEF2 from microtubules, enabling actin remodeling and formation of three-dimensional cell structures.

Funder

Canadian Cancer Society Research Institute

Cancer Research Society

Canadian Institutes for Health Research

Princess Margaret Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference119 articles.

1. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

2. A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation