Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists-Reference-Cited by-同舟云学术

Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists

Published:2019-03-26 Issue:574 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Mann Anika¹^ORCID,Moulédous Lionel²^ORCID,Froment Carine³,O’Neill Patrick R.⁴^ORCID,Dasgupta Pooja¹^ORCID,Günther Thomas¹^ORCID,Brunori Gloria⁵^ORCID,Kieffer Brigitte L.⁶,Toll Lawrence⁵^ORCID,Bruchas Michael R.⁷,Zaveri Nurulain T.⁸^ORCID,Schulz Stefan¹^ORCID

Affiliation:

1. Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Str. 1, Jena 07747, Germany.

2. Research Center on Animal Cognition, Center for Integrative Biology, Toulouse University, CNRS, UPS, 31062 Toulouse Cedex 09, France.

3. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, 31077 Toulouse Cedex 04, France.

4. Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Biomedical Science Department, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USA.

6. Douglas Research Center, Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC H3A 1A1, Canada.

7. Center for the Neurobiology of Addiction, Pain, and Emotion, Departments of Anesthesiology and Pharmacology, University of Washington, Seattle, WA 98195, USA.

8. Astraea Therapeutics LLC, Mountain View, CA 94043, USA.

Abstract

New antibodies to the opioid receptor NOP reveal the signaling diversity of its agonists.

Funder

Deutsche Forschungsgemeinschaft

Interdisziplinäres Zentrum für klinische Forschung Jena

Fonds Européen de Développement Régional, FEDER

French Ministry of Research with the Investissement d´Avenir Infrastrucutures Nationales en Biologie et Santé

NIH-NIDA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference127 articles.

1. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

2. cDNA cloning and regional distribution of a novel member of the opioid receptor family

3. ORL1, a novel member of the opioid receptor family

4. cDNA Cloning of an orphan opiate receptor gene family member and its splice variant

5. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

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