Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses-Reference-Cited by-同舟云学术

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

Published:2020-09-15 Issue:649 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gorby Claire¹^ORCID,Sotolongo Bellón Junel²^ORCID,Wilmes Stephan¹^ORCID,Warda Walid³^ORCID,Pohler Elizabeth¹,Fyfe Paul K.¹^ORCID,Cozzani Adeline⁴^ORCID,Ferrand Christophe³^ORCID,Walter Mark R.⁵^ORCID,Mitra Suman⁴,Piehler Jacob²^ORCID,Moraga Ignacio¹^ORCID

Affiliation:

1. Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee DD15EH, UK.

2. Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück, Barbarastraße 11, 49076 Osnabrück, Germany.

3. Université Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France.

4. Université de Lille, INSERM UMR1277 CNRS UMR9020–CANTHER and Institut pour la Recherche sur le Cancer de Lille (IRCL), Lille, France.

5. Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35243, USA.

Abstract

An IL-10 variant with higher affinity for a receptor subunit remains effective at low concentrations.

Funder

Wellcome

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference65 articles.

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4. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells;Fiorentino D. F.;J. Immunol.,1991

5. Defective IL-10 production in severe phenotypes of Crohn's disease

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