The Small GTPase ARF6 Stimulates β-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis-Reference-Cited by-同舟云学术

The Small GTPase ARF6 Stimulates β-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

Published:2013-03-05 Issue:265 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Grossmann Allie H.¹²³,Yoo Jae Hyuk³⁴,Clancy James⁵,Sorensen Lise K.³,Sedgwick Alanna⁵,Tong Zongzhong⁶,Ostanin Kirill⁶,Rogers Aaron¹,Grossmann Kenneth F.⁷⁸,Tripp Sheryl R.⁹,Thomas Kirk R.³⁷,D’Souza-Schorey Crislyn⁵,Odelberg Shannon J.³⁶⁷,Li Dean Y.³⁴⁷¹⁰¹¹

Affiliation:

1. Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.

2. ARUP Laboratories, University of Utah, Salt Lake City, UT 84108, USA.

3. Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA.

4. Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA.

5. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.

6. Navigen Inc., Salt Lake City, UT 84108, USA.

7. Department of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

8. Division of Medical Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84132, USA.

9. ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84112, USA.

10. Cardiology Section, VA Salt Lake City Health Care System, Salt Lake City, UT 84112, USA.

11. The Key Laboratory for Human Disease Gene Study of Sichuan Province, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China.

Abstract

WNT5A activates ARF6 to liberate β-catenin from adherens junctions, thereby increasing the amount that can mediate gene transcription.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.

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3. Convergence of Wnt, ß-Catenin, and Cadherin Pathways

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5. Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

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