A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Author:

Pulido Rafael12,Baker Suzanne J.3,Barata Joao T.4,Carracedo Arkaitz15,Cid Victor J.6,Chin-Sang Ian D.7,Davé Vrushank8,den Hertog Jeroen9,Devreotes Peter10,Eickholt Britta J.11,Eng Charis12,Furnari Frank B.13,Georgescu Maria-Magdalena14,Gericke Arne15,Hopkins Benjamin16,Jiang Xeujun17,Lee Seung-Rock18,Lösche Mathias19,Malaney Prerna8,Matias-Guiu Xavier20,Molina María6,Pandolfi Pier Paolo21,Parsons Ramon16,Pinton Paolo22,Rivas Carmen23,Rocha Rafael M.24,Rodríguez Manuel S.25,Ross Alonzo H.26,Serrano Manuel27,Stambolic Vuk28,Stiles Bangyan29,Suzuki Akira30,Tan Seong-Seng31,Tonks Nicholas K.32,Trotman Lloyd C.32,Wolff Nicolas33,Woscholski Rudiger34,Wu Hong35,Leslie Nicholas R.36

Affiliation:

1. Ikerbasque, Basque Foundation for Science, Bilbao, Spain.

2. BioCruces Health Research Institute, Barakaldo, Spain.

3. Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, USA.

4. Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.

5. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain.

6. Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.

7. Department of Biology, Queen’s University, Kingston, Ontario, Canada.

8. Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.

9. Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands.

10. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

11. Charité—Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German.

12. Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

13. Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.

14. The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

15. Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.

16. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

17. Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

18. Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.

19. Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

20. Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain.

21. Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA.

22. Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.

23. Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain.

24. Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil.

25. Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain.

26. Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

27. Spanish National Cancer Research Center (CNIO), Madrid, Spain.

28. Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

29. Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

30. Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan.

31. Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia.

32. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

33. Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France.

34. Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK.

35. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

36. Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK.

Abstract

With the discovery of an isoform based on an alternative translation start site, PTEN nomenclature needs an update.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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