Calmodulin and PI(3,4,5)P 3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production-Reference-Cited by-同舟云学术

Calmodulin and PI(3,4,5)P 3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production

Author:

Wang Xinxin¹,Boyken Scott E.²,Hu Jiancheng¹,Xu Xiaolu¹,Rimer Ryan P.¹,Shea Madeline A.³,Shaw Andrey S.¹,Andreotti Amy H.²,Huang Yina H.¹⁴⁵

Affiliation:

1. Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, IA 50011, USA.

3. Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA.

4. Department of Pathology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.

5. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.

Abstract

Calcium and lipids stimulate the kinase Itk through the same domain to promote proinflammatory T cell signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference67 articles.

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