FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility

Author:

Siesser Priscila F.1,Motolese Marta2,Walker Matthew P.1,Goldfarb Dennis13,Gewain Kelly1,Yan Feng1,Kulikauskas Rima M.4,Chien Andy J.4,Wordeman Linda5,Major Michael B.1

Affiliation:

1. Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Box 7295, Chapel Hill, NC 27599, USA.

2. Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.

3. Department of Computer Science, University of North Carolina at Chapel Hill, Box 3175, Chapel Hill, NC 27599, USA.

4. Division of Dermatology, Department of Medicine, University of Washington School of Medicine, Box 358056, 815 Mercer Street, Seattle, WA 98109, USA.

5. Department of Physiology and Biophysics, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA.

Abstract

Unlike related proteins, FAM123A interacts with microtubule-associated proteins and alters microtubule dynamics.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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