The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia-Reference-Cited by-同舟云学术

The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

Published:2011-07-12 Issue:181 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Liu Qin¹,Weng Hao-Jui¹,Patel Kush N.¹,Tang Zongxiang¹²,Bai Haihua¹³,Steinhoff Martin⁴⁵,Dong Xinzhong¹⁶

Affiliation:

1. Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

2. Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210046, China.

3. Inner Mongolia University for the Nationalities, School of Life Science, 22 Huolinhe Street, Tongliao City 028043, China.

4. Department of Dermatology, University of California, San Francisco, CA 94143, USA.

5. Department of Surgery, University of California, San Francisco, CA 94143, USA.

6. Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Sensory neurons perceive itch and heat-induced pain through two different receptors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference23 articles.

1. An Itch To Be Scratched

2. Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more

3. Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2

4. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice

5. Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin

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