Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds-Reference-Cited by-同舟云学术

Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds

Published:2010-03-23 Issue:114 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Saini Manoj¹,Sinclair Charles¹,Marshall Daniel¹,Tolaini Mauro²,Sakaguchi Shimon³,Seddon Benedict¹

Affiliation:

1. Division of Immune Cell Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

2. Division of Molecular Immunology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

3. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Abstract

Regulated expression of Zap70 determines whether thymocytes develop into CD4 + or CD8 + T cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

2. Signals involved in gamma/delta T cell versus alpha/beta T cell lineage commitment

3. Development and Selection of T Cells: Facts and Puzzles

4. Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

5. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

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