Vemurafenib Potently Induces Endoplasmic Reticulum Stress–Mediated Apoptosis in BRAFV600E Melanoma Cells-Reference-Cited by-同舟云学术

Vemurafenib Potently Induces Endoplasmic Reticulum Stress–Mediated Apoptosis in BRAFV600E Melanoma Cells

Published:2013-01-29 Issue:260 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Beck Daniela¹,Niessner Heike¹,Smalley Keiran S. M.²,Flaherty Keith³,Paraiso Kim H. T.²,Busch Christian¹,Sinnberg Tobias¹,Vasseur Sophie⁴⁵⁶⁷,Iovanna Juan Lucio⁴,Drießen Stefan⁸,Stork Björn⁸,Wesselborg Sebastian⁸,Schaller Martin¹,Biedermann Tilo¹,Bauer Jürgen¹,Lasithiotakis Konstantinos¹,Weide Benjamin¹,Eberle Jürgen⁹,Schittek Birgit¹,Schadendorf Dirk¹⁰,Garbe Claus¹,Kulms Dagmar¹¹¹²,Meier Friedegund¹

Affiliation:

1. Division of Dermatologic Oncology, Department of Dermatology, University of Tübingen, 72076 Tübingen, Germany.

2. Departments of Molecular Oncology and Cutaneous Oncology, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

3. Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

4. Centre de Recherche INSERM, 13288 Marseille, France.

5. Institut Paoli-Calmettes, 13288 Marseille, France.

6. Aix-Marseille University, 13288 Marseille, France.

7. CNRS, UMR7258, CRCM, 13288 Marseille, France.

8. Institute of Molecular Medicine, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.

9. Department of Dermatology and Allergy, Skin Cancer Center Charité, Charité–Universitätsmedizin Berlin, 10117 Berlin, Germany.

10. Department of Dermatology, University of Essen, 45122 Essen, Germany.

11. Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany.

12. Experimental Dermatology, Department of Dermatology, TU-Dresden, 01307 Dresden, Germany.

Abstract

Drug resistance in melanomas may be overcome by therapies that trigger endoplasmic reticulum stress.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. Final Version of 2009 AJCC Melanoma Staging and Classification

2. Mutations of the BRAF gene in human cancer

3. Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.;Satyamoorthy K.;Cancer. Res.,2003

4. Prognostic Significance of Activated Akt Expression in Melanoma: A Clinicopathologic Study of 292 Cases

5. The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma

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