miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR-Reference-Cited by-同舟云学术

miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR

Published:2013-07-30 Issue:286 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Balkhi Mumtaz Y.¹²,Iwenofu O. Hans²³,Bakkar Nadine⁴,Ladner Katherine J.¹²,Chandler Dawn S.⁵,Houghton Peter J.⁵,London Cheryl A.⁶,Kraybill William²⁷,Perrotti Danilo¹²,Croce Carlo M.¹²,Keller Charles⁸,Guttridge Denis C.¹²

Affiliation:

1. Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA.

2. Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

3. Department of Pathology and Laboratory Medicine, The Ohio State University, Columbus, OH 43210, USA.

4. Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA.

5. Center for Pediatric Oncology, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

6. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.

7. Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.

8. Pediatric Cancer Biology Program, Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Abstract

Loss of the decoy function of miR-29 destabilizes A20 transcripts, contributing to oncogenic activation of the transcription factor NF-κB in sarcomas.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference42 articles.

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2. Catalysis by a Multiprotein IκB Kinase Complex

3. A nuclear export signal in the N-terminal regulatory domain of Ikappa Balpha controls cytoplasmic localization of inactive NF-kappa B/Ikappa Balpha complexes

4. Regulation of NF-κB by deubiquitinases

5. Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

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