The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells-Reference-Cited by-同舟云学术

The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells

Published:2014-03-18 Issue:317 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Geimer Le Lay Anne-Solen¹,Oravecz Attila¹,Mastio Jérôme¹,Jung Claudia²³,Marchal Patricia¹,Ebel Claudine⁴,Dembélé Doulaye⁵,Jost Bernard⁵,Le Gras Stéphanie⁵,Thibault Christelle⁵,Borggrefe Tilman²⁶,Kastner Philippe¹⁷,Chan Susan¹

Affiliation:

1. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR 7104, Université de Strasbourg, 67404 Illkirch, France.

2. Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.

3. Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, 79104 Freiburg, Germany.

4. Flow Cytometry Facility, IGBMC, 67404 Illkirch, France.

5. IGBMC Microarray and Sequencing Platform, IGBMC, 67404 Illkirch, France.

6. Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany.

7. Faculté de Médecine, Université de Strasbourg, 67000 Strasbourg, France.

Abstract

By binding to Notch target genes, Ikaros shuts off the expression of these genes in T cells and prevents the development of T cell acute lymphoblastic leukemia.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

2. Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells

3. Hierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturation

4. Notch-Regulated Ankyrin-Repeat Protein Inhibits Notch1 Signaling: Multiple Notch1 Signaling Pathways Involved In T Cell Development

5. The Notch signaling pathway: Transcriptional regulation at Notch target genes

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