Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition-Reference-Cited by-同舟云学术

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

Published:2019-02-05 Issue:567 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Augert Arnaud¹^ORCID,Eastwood Emily¹^ORCID,Ibrahim Ali H.¹^ORCID,Wu Nan¹,Grunblatt Eli¹,Basom Ryan²^ORCID,Liggitt Denny³,Eaton Keith D.⁴^ORCID,Martins Renato⁴,Poirier John T.⁵^ORCID,Rudin Charles M.⁵^ORCID,Milletti Francesca⁶,Cheng Wei-Yi⁶^ORCID,Mack Fiona⁶,MacPherson David¹⁷^ORCID

Affiliation:

1. Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109, USA.

2. Genomics and Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109, USA.

3. Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.

4. Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98109, USA.

5. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Pharmaceutical Research and Early Development, Roche Innovation Center, New York, NY 10016, USA.

7. Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Abstract

Epigenetic therapy may induce tumor-suppressive Notch signaling in patients with small cell lung cancer.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference48 articles.

1. Comprehensive genomic profiles of small cell lung cancer

2. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

3. Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2 : CALGB 151111 (Alliance)

4. ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

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