Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

Author:

Augert Arnaud1ORCID,Eastwood Emily1ORCID,Ibrahim Ali H.1ORCID,Wu Nan1,Grunblatt Eli1,Basom Ryan2ORCID,Liggitt Denny3,Eaton Keith D.4ORCID,Martins Renato4,Poirier John T.5ORCID,Rudin Charles M.5ORCID,Milletti Francesca6,Cheng Wei-Yi6ORCID,Mack Fiona6,MacPherson David17ORCID

Affiliation:

1. Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109, USA.

2. Genomics and Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109, USA.

3. Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.

4. Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98109, USA.

5. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Pharmaceutical Research and Early Development, Roche Innovation Center, New York, NY 10016, USA.

7. Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Abstract

Epigenetic therapy may induce tumor-suppressive Notch signaling in patients with small cell lung cancer.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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