The hepatitis C virus protein NS3 suppresses TNF-α–stimulated activation of NF-κB by targeting LUBAC-Reference-Cited by-同舟云学术

The hepatitis C virus protein NS3 suppresses TNF-α–stimulated activation of NF-κB by targeting LUBAC

Author:

Chen Yongzhi¹²,He Liang¹²,Peng Yanan¹²,Shi Xiaodong¹,Chen Jizheng³,Zhong Jin⁴,Chen Xinwen³,Cheng Genhong¹⁵,Deng Hongyu¹

Affiliation:

1. CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China.

2. University of Chinese Academy of Sciences, Beijing 100049, China.

3. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

4. Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200025, China.

5. Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

A hepatitis C virus protein blocks NF-κB activation to suppress the antiviral immune response.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference48 articles.

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