Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function-Reference-Cited by-同舟云学术

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

Published:2012-11-27 Issue:252 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Brownlie Rebecca J.¹,Miosge Lisa A.²,Vassilakos Demetrios²,Svensson Lena M.³⁴,Cope Andrew³,Zamoyska Rose¹

Affiliation:

1. Institute for Immunology and Infection Research, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.

2. Molecular Immunology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

3. Academic Department of Rheumatology, Division of Immunology, Infection and Inflammatory Diseases, King’s College School of Medicine, Guy’s Campus, King’s College London, London SE1 1UL, UK.

4. Department of Experimental Medical Sciences, Immunology Section, Lund University, Lund SE-221 84, Sweden.

Abstract

Loss of the phosphatase PTPN22 enhances the functions of both effector and regulatory T cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference41 articles.

1. Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

2. Cooperative Inhibition of T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase

3. Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22

4. Role of PTPN22 in type 1 diabetes and other autoimmune diseases

5. A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

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