Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI

Author:

Brandsma Arianne M.1ORCID,Schwartz Samantha L.2,Wester Michael J.2ORCID,Valley Christopher C.2,Blezer Gittan L. A.1,Vidarsson Gestur3ORCID,Lidke Keith A.4,ten Broeke Toine1,Lidke Diane S.2ORCID,Leusen Jeanette H. W.1ORCID

Affiliation:

1. Immunotherapy Laboratory, Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

2. Department of Pathology and Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87102, USA.

3. Sanquin Research and Landsteiner Laboratory, Department of Experimental Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

4. Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131, USA.

Abstract

Cytokine stimulation drives nanoscale reorganization of surface FcγRI to augment antibody-dependent cellular functions.

Funder

National Institutes of Health

KiKa

European Federation of Immunological Societies

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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