Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis

Author:

Ding Xiangming1,Pan Hongya12,Li Jiong1,Zhong Qi13,Chen Xiaohong13,Dry Sarah M.45,Wang Cun-Yu1467

Affiliation:

1. Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. Department of Oral and Maxillofacial Surgery, Shanghai Ninth Hospital, Shanghai Jiaotong University, Shanghai 200011, China.

3. Department of Otolaryngology Head and Neck Surgery, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.

4. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.

5. Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

6. Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA 90095, USA.

7. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Epigenetic changes contribute to a positive feedback loop promoting AP1 activity that contributes to metastasis of squamous cell carcinoma to lymph nodes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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