Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation-Reference-Cited by-同舟云学术

Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation

Published:2018-09-04 Issue:546 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sheffels Erin¹^ORCID,Sealover Nancy E.¹^ORCID,Wang Chenyue¹,Kim Do Hyung¹^ORCID,Vazirani Isabella A.¹,Lee Elizabeth¹,M. Terrell Elizabeth²,Morrison Deborah K.²^ORCID,Luo Ji³,Kortum Robert L.¹^ORCID

Affiliation:

1. Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

2. Laboratory of Cell and Developmental Signaling, National Cancer Institute (NCI)–Frederick, Frederick, MD 21702, USA.

3. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Mutant RAS–selective dependence on the GEF SOS2 reveals tumor cell sensitivity to kinase inhibitors.

Funder

National Cancer Institute

Congressionally Directed Medical Research Programs

Uniformed Services University of the Health Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference66 articles.

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5. Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.

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